Specification
| Description | Recombinant protein from the full-length sequence of homo sapiens crystallin alpha A (CRYAA) (NM_000394). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | P02489 |
| Entry Name | CRYAA_HUMAN |
| Gene Names | CRYAA CRYA1 HSPB4 |
| Alternative Gene Names | CRYA1 HSPB4 |
| Alternative Protein Names | Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4) [Cleaved into: Alpha-crystallin A(1-172); Alpha-crystallin A(1-168); Alpha-crystallin A(1-162)] |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 173 |
| Molecular Weight(Da) | 19909 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS |
Background
| Function | FUNCTION: Contributes to the transparency and refractive index of the lens (PubMed:18302245). In its oxidized form (absence of intramolecular disulfide bond), acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions (PubMed:22120592, PubMed:31792453, PubMed:18199971, PubMed:19595763). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:28935373). {ECO:0000269|PubMed:18199971, ECO:0000269|PubMed:19595763, ECO:0000269|PubMed:22120592, ECO:0000269|PubMed:28935373, ECO:0000269|PubMed:31792453, ECO:0000303|PubMed:18302245}. |
| Pathway | |
| Protein Families | Small heat shock protein (HSP20) family |
| Tissue Specificity | Expressed in the eye lens (at protein level). {ECO:0000269|PubMed:12356833, ECO:0000269|PubMed:23255486}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |